property | value |
---|---|
Substitutive name | Salvinorin B |
Systematic name | methyl (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(furan-3-yl)-9-(methoxymethoxy)-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,8,9,10a-octahydro-1H-benzo[f]isochromene-7-carboxylate |
salvinorin b methoxymethyl ether (2-o-methoxymethylsalvinorin b, or 2-mmsb) is a semi-synthetic analogue of the natural product salvinorin a which is used in scientific research. it has a longer duration of action of around 2–3 hours, compared to less than 30 minutes for salvinorin a, and has increased affinity and potency at the κ-opioid receptor. like the related compound herkinorin, salvinorin b methoxymethyl ether is made from salvinorin b, which is most conveniently made from salvinorin a by deacetylation, as while both salvinorin a and salvinorin b are found in the plant salvia divinorum, salvinorin a is present in larger quantities.
salvinorin b methoxymethyl ether has a ki of 0.60 nm at the κ opioid receptor, and is around five times more potent than salvinorin a in animal studies, although it is still only half as potent as its stronger homolog salvinorin b ethoxymethyl ether.
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