1B-LSD

Introduction

1B-LSD is  a psychedelic of the lysergamide class. 1B-LSD is closely related to LSD and produces near-identical effects.
It’s psychedelic effects are produced by acting on serotonin receptors in the brain.
The original synthesis date of 1B-LSD is unknown. 1B-LSD has no prior record in the scientific literature.

User reports indicate that the subjective effects of 1B-LSD are extremely similar to those of 1P-LSD. 1B-LSD is theorized to act as a prodrug for LSD. The similarities in chemical structure between 1B-LSD and LSD predicts a near-identical effect profile, likely differing mainly in its rate of absorption and duration. Characteristics effects include geometric visual hallucinations, time distortion, enhanced introspection, and ego loss. Its classical psychedelic effects and favorable tolerability has led it to become popular among novel psychoactive substance users who use it interchangeably with LSD.Very little data exists about the pharmacological properties, metabolism, and toxicity of 1B-LSD. It is presumed to have a similar toxicity and risk profile as LSD, although no evidence currently exists to support this. It is highly advised to use harm reduction practices if using this substance.

Chemistry

1B-LSD is a molecule of the lysergamide family. It is similar to LSD and is named for the butyryl group bound to the nitrogen of the polycyclic indole group of LSD.The tetracyclic ergoline is characteristic of the chemical structure of ergot alkaloids. In contrast to LSD, 1B-LSD has an additional N1-butyryl group. Chemical modifications in the N1 position are among the most frequently performed changes in the ergoline system, as the In dole nitrogen is easily accessible for alkylations, acylations, Mannich reactions and Michael additions.

Pharmacology

Based on its structural similarity to LSD, 1B-LSD likely acts as a partial agonist at the 5-HT2A receptor.The psychedelic effects are thought to primarily come from its efficacy at the 5-HT2A receptors distributed throughout the brain. 1B-LSD also likely displays binding activity at a wide range of monoamine receptors, such as those for dopamine and norepinephrine. However, there is currently no data to support these claims.It has been theorized that 1B-LSD (as well as the acyl homologs 1P-LSD and ALD-52) is deacylated in the body to LSD by elimination of butyric acid, as shown by studies with human blood serum.[5]

Effects

Physical effects

Stimulation

Spontaneous bodily sensations

Physical euphoria

Tactile enhancement

Stamina enhancement

Appetite suppression

Bodily control enhancement

Difficulty urinating

Excessive yawning

Nausea

blood pressure increases

Increased heart rate

More perspiration

Muscle contractions

Muscle spasms

Pupil dilation

Increased salivation

Vasoconstriction

Seizure

Visual effects

Colour enhancement

Pattern recognition enhancement

Visual acuity enhancement

Drifting

Colour shifting

Colour tinting

Tracers

After images

Depth perception distortions

Perspective distortions

Recursion

Symmetrical texture repetition

Scenery slicing

Transformations

Machinescapes

Internal hallucination

External hallucination

Cognitive effects

Analysis enhancement

Anxiety

Paranoia

Conceptual thinking

Creativity enhancement

Emotion enhancement

Novelty enhancement

Personal bias suppression

Personal meaning enhancement

Focus enhancement

Immersion enhancement

Suggestibility enhancement

Cognitive euphoria

Delusion

Déjà vu

Ego replacement

Increased libido

Laughter fits

Memory suppression

Ego death

Multiple thought streams

Personality regression

Thought acceleration

disorganization of thoughts

Time distortion

Wakefulness

Auditory effects

Auditory enhancement

Increased music appreciation

Multi-sensory effects

Synaesthesia

Transpersonal effects

Spirituality enhancement

Existential self-realization

Unity and interconnectedness

Substance properties

Effects dosage and effects duration