Proscaline

4-propyloxy-3,5-dimethoxyphenethylamine (commonly known as proscaline) is a synthetic psychedelic substance of the phenethylamine chemical class that produces modified mescaline-like hallucinogenic effects when administered. it has structural and pharmacological properties similar to its parent drug mescaline as well as to its analogs such as isoproscaline, escaline and allylescaline.

the synthesis of proscaline was first published by david e. nichols in 1977. around the same time, alexander shulgin sampled and evaluated the chemical at doses up to 60mg, estimating its potency as five times that of mescaline. shulgin later documented proscaline in his 1991 book “pihkal: a chemical love story”.

today, proscaline is primarily used as a recreational drug, rarely if ever sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors. it is relatively obscure and has only a short history of human use.

chemistry

proscaline, or 3,5-dimethoxy-4-propyloxyphenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino -nh2 group through an ethyl chain. proscaline contains two methoxy functional groups ch3o- which are attached to carbons r3 and r5 as well as an additional propyloxy group at carbon r4 of the phenyl ring. proscaline is the 4-propyloxy analog of mescaline, which means it has one additional carbon at the alkyloxy group than escaline, another closely related mescaline analog.

pharmacology

proscaline’s psychedelic effects are believed to come from its efficacy at the 5-ht_2a receptor as a partial agonist. however, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.