|Common names||3-FA, PAL-353|
3-fluoroamphetamine (3-fa) is a synthetic ring-substituted fluorinated amphetamine compound that produces potent classical stimulant effects that has been claimed to be “almost equipotent” with methamphetamine. it is one part of a series of designer fluorinated amphetamine analogs such as 2-fa, 2-fma, 3-fea, and 4-fa that are known for their euphoric and stimulating effects and growing popularity as research chemical substitutes for classical street stimulants.
3-fa is rarely found on the streets, and only sometimes sold as a grey market research chemical through online vendors.
3-fa, or 3-fluoroamphetamine, is a synthetic molecule of the amphetamine class. molecules of the amphetamine class contain a phenethylamine core featuring a phenyl ring bound to an amino (nh2) group through an ethyl chain with an additional methyl substitution at rα (i.e. amphetamines are alpha-methylated phenethylamines). 3-fa does not contain a methyl group bound to the terminal amine rn of the amphetamine core, which renders it structurally and functionally similar to amphetamine. 3-fa is the 3-fluorinated analogue of amphetamine.
although 3-fa has not been formally studied on the same level as traditional amphetamines, it is not unreasonable to assume that just like other substituted amphetamines with substitutions at similar positions (with the notable exception of 4-fa), it most likely acts primarily as both a dopamine and norepinephrine releasing agent, with modest selectivity for serotonin. this means it effectively increases the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally clear and reuptake those molecules from the synaptic cleft for future reuse. this allows dopamine and norepinephrine to accumulate within the brain to extra-endogenous degrees, which is known to produce stimulating, motivatory and euphoric effects in humans.