3-meo-pcmo (4-[1-(3-methoxyphenyl)cyclohexyl]morpholine) is a new morpholine analogue of 3-meo-pcp. it is a dissociative nmda receptor antagonist, sigma receptor and anesthetic drug of the arylcyclohexylamine chemical class with a potency of less than 1/10th of that of 3-meo-pcp.
this compound induces a state referred to as “dissociative anesthesia” when ingested and is therefore used as a recreational drug. 3-meo-pcmo has recently become easily accessible through online research chemical vendors where it is being sold as a designer drug.
although very little is known about this compound, similar morpholine analogues of phencyclidine have been researched before.
3-meo-pcmo, or 4-[1-(3-methoxyphenyl)cyclohexyl]morpholine, is classified as an arylcyclohexylamine drug. ayrlcyclohexylamine drugs are named for their structures which include a cyclohexane ring bound to an aromatic ring along with an amine group at the same location. the aryl substituent of 3-meo-pcmo is a phenyl ring with a methoxy (ch3-o-) substituent at r3, which is bound to a six-membered cyclohexyl ring. bound at the same location on the cyclohexyl ring r1 is an amine group which is incorporated into a morpholine ring as r4.
morpholine is a six-membered heterocyclic ring with an oxygen subsitutent at r1. 3-meo-pcmo is a morpholine analogue to 3-meo-pcp, which lacks an oxygen moiety in its six-membered amine ring (a piperidine ring instead of a morpholine ring).
due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other arylcyclohexylamine dissociatives such as 3-meo-pcp, pcp and mxe. with this in mind, 3-meo-pcmo is thought to act as an nmda receptor antagonist. nmda receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. dissociatives close the nmda receptors by blocking them. this disconnection of neurons leads to loss of feeling, difficulty moving, and eventually this substance’s equivalent of the “k-hole.”