25b-nboh (also known as 2c-b-nboh and nboh-2cb) is novel synthetic psychedelic substance of the phenethylamine chemical class that produces an array of visually-dominant and stimulating psychedelic effects when administered. it is a closely related analog of 25b-nbome and is reported to share most of its properties with the exception of a moderately reduced potency and a shorter duration.
the name 25b-nboh, which is short-hand for 2c-b-nboh, is a derivative of the phenethylamine psychedelic 2c-b. it was first synthesized and documented in 2011 by martin hansen at the university of copenhagen.
it is worth noting that compounds of the nboh family are not orally active and should be administered sublingually by placing and holding it into one’s mouth and allowing it to absorb over a period of 15-25 minutes.
extremely little is known about the pharmacological properties, metabolism, and toxicity of 25b-nboh in humans. it has no history of human use before being sold online as a designer drug in 2011. it is closely related to members of the 25x-nbome series, which have been associated with many hospitalizations and deaths. anecdotal reports suggest that this substance may be difficult to use safely due to its highly sensitive dose-response and unpredictable effects.
25b-nboh or 2c-b-nboh, is a serotonergic n-benzyl derivative of the substituted phenethylamine psychedelic known as 2c-b. 25b-nboh is a substituted phenethylamine with methoxy groups ch3o- attached to carbons r2 and r5 as well as an bromine atom attached to carbon r4. it differs from 2c-b structurally through a substitution on the amine (nh2) with a 2-hydroxybenzyl (boh) group. 25b-nboh shares this 2-hydroxybenzyl substitution with other chemicals of the nboh family. this nboh addition is comprised of a hydroxy ether oh- bound to a benzene ring at r2.
this compound is pharmacologically unique when compared to other psychedelics due to the unusually high selectivity it displays for various serotonin receptors. it is notable as one of the most selective agonist ligands for the 5-ht2a receptor with a pec50 value of 9.87 nmit has a pki of 0.061 nm at the human 5ht2a receptor, similar to the better-known compound 25b-nbome.
however, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.