25C-NBOMe

25c-nbome (also known as cimbi-36 and 2c-c-nbome) is a novel psychedelic substance of the phenethylamine class. it is a member of the 25x-nbome series, a recently discovered group of potent psychedelic compounds derived from the 2c-x family.

the name 25c-nbome, which is short-hand for 2c-c-nbome, is a derivative of the phenethylamine psychedelic 2c-c. it was discovered in 2003 by ralf heim at the free university of berlin, and subsequently investigated by a team at purdue university led by david nichols. it has been studied in its radiolabelled form as a potential ligand for mapping the distribution of serotonin-2a receptors in the brain using positron emission tomography (pet). the first reports of human use appeared in 2010 following its appearance on the online research chemical market.

subjective effects include stimulation, open and closed-eye visuals, time distortion, ego loss, and euphoria. 25c-nbome’s effects are sometimes compared to those of lsd or dox. however, it is reported to have stronger visual effects and less cognitive and emotional effects like ego loss and introspection. additionally, 25c-nbome is reported to be considerably more stimulating than other psychedelics. serious side effects are more common and include nausea, muscle tension, anxiety, cardiovascular effects, and seizures.

it is worth noting that members of the nbome series are not orally active and should be administered sublingually (by holding it into one’s mouth and allowing it to absorb over a period of 15 minutes). 25c-nbome can also be vaporized and inhaled for more rapid and powerful effects and a shorter duration. however, this route of administration is highly advised against due to the difficulties of measuring and handling substances that are active in the microgram range as it significantly increases the risk of overdose. 25c-nbome is also sometimes sold as a counterfeit version of lsd due to its similar effects and ability to be laid onto blotter paper.

very little is known about the pharmacological properties, metabolism, and toxicity of 25c-nbome. however, it has been associated with many deaths and hospitalizations which suggests that it has a significantly worse toxicity profile than classical psychedelics like lsd or psilocybin mushrooms. along with its highly sensitive dose-response and unpredictable effects, many reports also suggest that this substance may be overly difficult to use safely. it is highly advised to use harm reduction practices if using this substance.

chemistry

25c-nbome or 2c-c-nbome is a serotonergic n-benzyl derivative of the substituted phenethylamine psychedelic known as 2c-c. 25c-nbome is a substituted phenethylamine with methoxy groups ch₃o- attached to carbons r₂ and r₅ as well as a chlorine atom attached to carbon r₄. it differs from 2c-c structurally through a substitution on the amine (nh2) with a 2-methoxybenzyl (bome) group as shown in the image to the right. 25c-nbome shares this 2-methoxybenzyl substitution with other chemicals of the nbome family. this nbome addition contains a methoxy ether ch₃o- bound to a benzene ring at r₂.

pharmacology

25c-nbome has efficacy at the 5-ht_2a receptor where it acts as a potent partial agonist. however, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

in comparison to 2c-c, the addition of an nbome group to the structure results in a sixteen fold increase in potency, allowing even the most extreme of dosages to fit in liquid form onto tabs and blotter paper, which people often mistake for lsd. in comparison to lsd however it is only a third of the potency.