|Common names||Diethyltryptamine, DET|
diethyltryptamine (also known as n,n-det or det) is a synthetic psychedelic tryptamine and a close structural analog of dmt (dimethyltryptamine). it is extremely uncommon and has little history of human usage.
det, or n,n-diethyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine class. tryptamines share a core structure comprised of a bicylic indole heterocycle attached at r3 to an amino group via an ethyl side chain. dmt contains two ethyl groups ch2ch3– bound to the terminal amine rn of its tryptamine backbone. det has many substituted analogues such as 4-ho-det (“ethocin”).
due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other tryptamine psychedelics such as psilocin and dmt. with this in mind, det is thought to act as an 5-ht2a partial agonist.
unlike dmt, the ethyl groups add protection against the monoamine oxidase enzyme system, allowing det to be orally active, while dmt is not.
however, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.