4-AcO-DET

4-aco-det (4-acetoxy-n,n-diethyltryptamine, ethacetin) is an obscure synthetic psychedelic tryptamine. there is very little information on the human pharmacology or toxicity of 4-aco-det, although analytical methods have been developed for its detection. today it is either used recreationally as a designer drug or as an entheogenic compound and is typically acquired through the use of online research chemical vendors. it remains relatively rare and has very little documented history of human usage.

4-aco-det is the acetylated form of 4-ho-det (also known as ethocin) and is a higher homolog of 4-aco-dmt and 4-aco-met. like the aforementioned compounds, it is commonly hypothesized to act principally as a prodrug for their respective hydrolyzed counterparts (e.g. 4-ho-dmt, 4-ho-met and 4-ho-det). in theory, they would become inactive until they are deacetylated in the body, although there is on-going discussion as to whether they might display their own intrinsic activity.

chemistry

4-aco-det, or 4-acetoxy-n.n-diethyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine class. tryptamines share a core structure comprised of a bicylic indole heterocycle attached at r₃ to an amino group via an ethyl side chain. 4-aco-det is substituted at r₄ of its indole heterocycle with an acetoxy (aco) functional group ch₃coo−. it also contains isopropyl and methyl chains bound to the terminal amine r_n of its tryptamine backbone (det).

4-aco-det is the n-substituted diethyl homolog of 4-ho-dmt (psilocin). 4-aco-det is the acetate ester analog of det and the n-substituted diethyl analog of 4-aco-dmt.

pharmacology

like with most psychedelic tryptamines, 4-aco-det is thought to act principally as a 5-ht_2a partial agonist. the psychedelic effects are believed to come from 4-aco-det’s binding efficacy at the 5-ht_2a receptors.

however, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.