Methoxphenidine

methoxphenidine (also known as mxp) is a lesser-known novel dissociative substance of the diarylethylamine class. it is an nmda antagonist with subjective effects similar to those of ketamine and phencyclidine (pcp). it is structurally related to diphenidine and ephenidine.

methoxphenidine has been studied alongside other diarylethylamines as a treatment for neurotoxic injuries.
the first reports of human recreational use appeared shortly after the 2013 u.k. arylcyclohexylamine ban, during which it and diphenidine began to be sold in powder and tablet form on the online research chemical market.
it was initially marketed by vendors as a replacement for the highly popular methoxetamine (mxe) despite little to no evidence that it possessed similar effects.

subjective effects include depersonalization, disconnective effects, conceptual thinking, increased music appreciation, and euphoria. methoxphenidine belongs to a class of substances that can induce a hallucinogenic state known as “dissociative anesthesia”, in which the user feels detached from their bodies.

very little data exists about the pharmacological properties, metabolism, and toxicity of methoxphenidine and it has an extremely limited history of human usage. a number of fatal and non-fatal overdoses have been linked to the abuse of diarylethylamines. additionally, a number of user reports suggest that they may carry different and more pronounced risks than traditional dissociatives. it is highly advised to use harm reduction practices if using this substance.

history and culture

methoxphenidine is an example of a designer drug, specifically chosen to mimic the functional or structural features of commonly used illicit substances and circumvent government regulation.

chemistry

methoxphenidine, or 2-meo-diphenidine, is a synthetic compound of the diarylethylamine class. methoxphenidine’s chemical structure contains a substituted phenethylamine skeleton with an additional phenyl ring bound to r_α. the terminal amino group of the phenethylamine chain is incorporated into a piperidine ring. hence, methoxphenidine belongs to the piperidine dissociative class of compounds.

methoxphenidine is a structural analog of diphenidine, featuring a methoxy group at the two position of a phenyl group.

pharmacology

mxp acts as an nmda receptor antagonist. nmda receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. dissociatives close the nmda receptors by blocking them. this disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the “k-hole.”

although it has not been formally studied, the feelings of physical and emotional euphoria which many users report suggests that it may also have action as a dopamine and / or a noradrenaline reuptake inhibitor.